- #Omer koc university hospitals of cleveland skin
- #Omer koc university hospitals of cleveland software
Four patients are alive (130-287 days), 3 with extensive chronic GVHD. Four patients died (2 from sepsis, 1 from acute GVHD, and 1 from chronic GVHD).
#Omer koc university hospitals of cleveland skin
Six had skin involvement, 5 had gastrointestinal involvement, and 1 had liver involvement. Seven of 8 patients developed severe acute GVHD (grade III, n=5 grade IV, n=2). One patient had secondary engraftment failure at 3 months and another had mixed chimerism at day 100.
There was a rapid decrease in epidermal CD1a+ cells by day of transplantation. Two patients received all 14 prescribed UV-B treatments (cumulative doses of 20 mJ/cm2, respectively) and 6 patients received 8 to 13 treatments with a cumulative dose range of 528-3465 mJ/cm2. The conditioning regimen and the UV-B therapy were well tolerated. GVHD prophylaxis included cyclosporine, methylprednisolone, and escalating doses of narrowband UV-B (311 nm) according to skin tolerance, 3 days a week, from 10 days before to 28 days after transplantation. Conditioning regimen was fludarabine 30 mg/m2 intravenously for 5 days, cyclophosphamide 1 g/m2/d intravenously for 2 days, and equine antithymocyte globulin 30 mg/kg/d for 2 days. Allogeneic peripheral blood stem cells were obtained from matched related (n=5) or matched unrelated (n=3) donors. Eight patients (median age, 55.5 years range, 32-65 years) with hematologic malignancies were included. This study tested the feasibility of using UV-B phototherapy that was initiated before grafting and continued until engraftment to determine its effect on transplantation outcome. We hypothesized that whole-body UV-B therapy would improve donor engraftment and decrease the incidence and severity of GVHD that is associated with decreased intensity allogeneic hematopoietic stem cell transplantation. This is an earnest appeal that all scholars embrace fairness and responsibility in developing plagiarism-free manuscripts.Whole-body UV-B phototherapy has been used for the treatment of graft-versus-host disease (GVHD) of the skin and has systemic immunosuppressive and tolerogenic effects. Plagiarism is a severe breach of commitment towards research and development and it also detracts the value of original and honest scholarly work. Otherwise the author needs to change the language completely and use his/ her own language. In case author wants to use material from the other work then it is mandatory to cite the same in references. The editor may accept such a translated publication to bring it to the attention of a wider audience. In the case of a publication being submitted that was originally published in another language, the title, date and journal of the original publication must be identified by the authors, and the copyright must be obtained. If such is the case then manuscript will not be given manuscript tracking ID and the same is sent back to author for revision and resubmission. In case 20% - 25% of the paper is found to be plagiarized, the article is liable to be rejected and the same is notified to the author. If plagiarism is detected by Quality Control Team/ Editorial Board Members/Reviewers at the time of Manuscript Submission Confirmation or in any stage of manuscript processing then the authors are alerted and asked to rewrite the content or to cite the references from where the content has been taken. The following aspects are excluded at the time of conducting plagiarism check. If plagiarism is detected at any stage of publication process before and after acceptance or during editing or proof reading stage, the authors are alerted to make the changes and cite the original source.
#Omer koc university hospitals of cleveland software
In order to support the ethical publication initiative, the quality control team uses iThenticate software to check plagiarism in the submitted manuscripts. We believe that Plagiarism is not only illegal but also unethical and caustic. We judge the quantity and quality of the copied content for its relevance to the original source. Journal of Genetic Medicine and Gene Therapy is committed to protect the reliability of the scholarly manuscript in all aspects of research and publishing ethics.
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